Life Science

4Bio Analyzer Biochemical analyzer, optical

DESCRIPTION

The 4BioCell biochemistry analyzers offer a quick and easy way of determining the substrate, metabolites and product in your cell culture or fermentation sample. The proven photometric measuring method offers high precision, accuracy and linearity.

Advantages:

-Low sample volume

-Low calibration routine

-Low maintenance

-23 parameters (+ Open Channel)

-Flexible by simple changing of the parameters, no combination assays

-Easy operation with first-class software and supplied hardware

-Cooled reagent tray

-Long on-board stability (30 days)

-Automatic test repetition with dilution

-Automatic pre-dilution up to 1: 100*

-CFR part 11 compliance

-Liquid sensors for detecting the fill level in samples, reagent and tanks

* The automatic sample dilution starts when the maximum linearity limit is exceeded, so that you always get a result even with highly concentrated samples. The cooled reagents allow a CV of less than 10% to be maintained for many days without recalibrating the device.

Screen_Worklist_2
Screen_REAGENTS_2

Details

All parameters can be measured independently of one another.

  • Acetate
  • Ammonium
  • Calcium
  • Chloride
  • Cholesterol
  • Copper
  • Ethanol
  • Glucose
  • Glutamate
  • Glutamine
  • Glycerin
  • High content IgG
  • High content protein
  • High sensitivity IgG
  • High sensitivity protein
  • Inorganic Phosphorus
  • Iron
  • Lactate
  • LDH
  • Magnesium
  • Potassium
  • Sodium
  • Triglycerides
  • Open Channcel (other available assays)

We have three analyzers of different sizes and throughput in our portfolio to offer you the best solution for your laboratory. From entry level to highly efficient, all analyzers combine innovation and ease of use of the highest quality.

4BioCore – for small laboratories

4BioCompact – for medium-sized laboratories

4BioCombine – for large laboratories

4BIOCORE
4BIOCOMPACT
4BIOCOMBINE
Throughput [Tests/h]
150
200
300
Reagent positions (cooled)
20
15
30
Probe positions
10, cooled
46
46
Size (WxHxD) [cm]
38x40x60
60x49x62
85x49x62
Weight [kg]
20
38
55
Cuvette
96 disposable cuvette
80 BIONEX cuvette incl. washing station
80 BIONEX cuvette incl. washing station
Dilution
Automatic pre-run and rerun dilutions in cuvettes and/or needle up to 1: 100
Automatic pre-run and rerun dilutions in cuvettes and/or needle up to 1: 100
Automatic pre-run and rerun dilutions in cuvettes and/or needle up to 1: 100
Pipette
Capacitive liquid sensor
Capacitive liquid sensor, needle shock sensor
Capacitive liquid sensor, needle shock sensor, two pipetting arms
Barcode reader
Barcode recognition of samples and reagents
Barcode recognition of samples and reagents
Barcode recognition of samples and reagents
Software
External industrial touch PC with user-friendly software
External industrial touch PC with user-friendly software
External industrial touch PC with user-friendly software
Probe volume [µL]
min. 150
min. 300
min. 300

Linearity of the parameters

ASSAY
UNIT
MIN
MAX
UNIT
MIN
MAX
Acetate
mmol/L
0,33
21,65
g/L
0,02
1,3
Ammonium
mmol/L
0,2
10
mg/L
3,4
170
Calcium
mmol/L
0,1
5
g/L
4
200
Chloride
mmol/L
40
170
g/L
1,42
6,03
Cholesterol
mmol/L
0,8
19,4
g/L
0,3
7,5
Copper
mmol/L
4
79
mg/L
0,25
5
Ethanol
mmol/L
2,17
79,95
g/L
0,1
3,5
Glucose
mmol/L
0,22
22,2
g/L
0,04
4
Glutamate
mmol/L
0,1
10,2
g/L
0,015
1,5
Glutamine
mmol/L
0,5
10,2
g/L
0,073
1,49
Glycerin
mmol/L
0,02
27
g/L
0,002
2,5
hcIgG
g/L
1,75
35
–
–
–
hcProtein
g/L
2
150
–
–
–
hsIgG
mg/L
8
300
–
–
–
hsProtein
g/L
0,05
3
–
–
–
Iron
µmol/L
4
179
mg/L
0,22
10
Lactate
mmol/L
0,4
62
g/L
0,04
5,58
LHD
U/L
15
1200
–
–
–
Magnesium
mmol/L
0,2
2,05
mg/L
0,5
50
Phosphate
mmol/L
0,36
9,69
mg/L
11,15
300
Potassium
mmol/L
2
8
mg/L
7,82
32,28
Sodium
mmol/L
10
180
g/L
2,3
4,14
Triglycerides
mmol/L
0,1
11,3
mg/L
10
1000

FAQ

Which applications are the 4BioAnalysers suitable for?

The 4BioAnalyser are suitable for determining substrates, metabolites and products in cell culture and fermentation samples. Typical applications include process development, media optimisation, bioprocess monitoring and monitoring of key nutrient and metabolic parameters. 

A total of 23 parameters are available, along with an open channel for additional assays. These include glucose, lactate, glutamine, glutamate, ammonium, acetate, ethanol, glycerol, electrolytes, LDH, IgG and protein. All parameters can be selected independently. 

Photometric analysis measures the change in light absorption caused by a reaction. The measured absorbance is converted into a concentration using calibration data. This established method enables precise, analyte-specific determination of various substrates, metabolites and products. 

The 4BioAnalysers are primarily intended for cell culture supernatants, fermentation samples and comparable biotechnological sample matrices. Whether dilution, centrifugation or other preparation is required depends on turbidity, cell content, concentration and the selected assay. 

The 4BioCore achieves a throughput of up to 150 tests per hour. The system has ten refrigerated sample positions and 20 refrigerated reagent positions. It also accommodates 96 disposable cuvettes. 

The 4BioCompact can process 200 tests per hour. It has 15 refrigerated reagent positions and 46 sample positions. The 4BioCompact uses reusable cuvettes. 

The 4BioCombine holds reagents for up to 30 assays under refrigeration and accommodates 46 samples. It achieves a throughput of up to 300 measurements per hour. 

The specified minimum sample volume for the 4BioCore is 150 µl (for the other versions minimum 300 µl). The volume actually consumed during testing depends on the assay, the number of requested parameters and any repeat measurements or dilution steps.

Yes, assays can be selected independently. No predefined assay combinations are required. This allows the system to be flexibly adapted to different processes and changing analytical requirements. 

If a result exceeds an assay’s linear measuring range, the system can automatically dilute the sample and repeat the measurement. Automatic predilution and repeat dilution are possible at ratios of up to 1:100. This allows samples with higher concentrations to be processed without manual dilution. 

Samples and reagents can be identified using barcodes. Operation and results management are handled via an external industrial touchscreen PC running the associated software. The system supports traceable documentation of measurements and is designed to meet the requirements of 21 CFR Part 11. 

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